CHEMISTRY AND FUNCTIONAL-ROLE OF THE INVARIANT CHAIN

被引：76

作者：

CRESSWELL, P

机构：

[1] Yale University School of Medicine, New Haven, CT

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 01期

关键词：

D O I：

10.1016/0952-7915(92)90131-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The invariant chain has two critical properties that regulate the function of the class II glycoproteins with which it associates. It prevents class II molecules from binding antigenic peptides during the early stages of their assembly and transport, and it contains a signal that drives the assembled class II-invariant chain complex to an endocytic compartment. Dissociation of the invariant chain in this compartment is believed to generate class II molecules capable of binding antigenic peptides.

引用

收藏

页码：87 / 92

页数：6

相关论文

共 43 条

[21] MONENSIN PREVENTS TERMINAL GLYCOSYLATION OF THE N- AND O-LINKED OLIGOSACCHARIDES OF THE HLA-DR-ASSOCIATED INVARIANT CHAIN AND INHIBITS ITS DISSOCIATION FROM THE ALPHA-BETA-CHAIN COMPLEX [J].

MACHAMER, CE ;

CRESSWELL, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1287-1291

[22]

MACHAMER CE, 1982, J IMMUNOL, V129, P2564

[23] INVARIANT CHAIN TRIMERS ARE SEQUESTERED IN THE ROUGH ENDOPLASMIC-RETICULUM IN THE ABSENCE OF ASSOCIATION WITH HLA CLASS-II ANTIGENS [J].

MARKS, MS ;

BLUM, JS ;

CRESSWELL, P .

JOURNAL OF CELL BIOLOGY, 1990, 111 (03) :839-855

[24]

MARKS MS, 1986, J IMMUNOL, V136, P2519

[25] DEFECTIVE PROCESSING AND PRESENTATION OF EXOGENOUS ANTIGENS IN MUTANTS WITH NORMAL HLA CLASS-II GENES [J].

MELLINS, E ;

SMITH, L ;

ARP, B ;

COTNER, T ;

CELIS, E ;

PIOUS, D .

NATURE, 1990, 343 (6253) :71-74

[26] EFFICIENT CELL-SURFACE EXPRESSION OF CLASS-II MHC MOLECULES IN THE ABSENCE OF ASSOCIATED INVARIANT CHAIN [J].

MILLER, J ;

GERMAIN, RN .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (05) :1478-1489

[27]

MILLER J, 1988, P NATL ACAD SCI USA, V85, P1358

[28] THE BIOSYNTHETIC-PATHWAY OF MHC CLASS-II BUT NOT CLASS-I MOLECULES INTERSECTS THE ENDOCYTIC ROUTE [J].

NEEFJES, JJ ;

STOLLORZ, V ;

PETERS, PJ ;

GEUZE, HJ ;

PLOEGH, HL .

CELL, 1990, 61 (01) :171-183

[29] 4 IA INVARIANT CHAIN FORMS DERIVE FROM A SINGLE GENE BY ALTERNATE SPLICING AND ALTERNATE INITIATION OF TRANSCRIPTION TRANSLATION [J].

OSULLIVAN, DM ;

NOONAN, D ;

QUARANTA, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (02) :444-460

[30] SEGREGATION OF MHC CLASS-II MOLECULES FROM MHC CLASS-I MOLECULES IN THE GOLGI-COMPLEX FOR TRANSPORT TO LYSOSOMAL COMPARTMENTS [J].

PETERS, PJ ;

NEEFJES, JJ ;

OORSCHOT, V ;

PLOEGH, HL ;

GEUZE, HJ .

NATURE, 1991, 349 (6311) :669-676

← 1 2 3 4 5 →