TOWARDS VACCINES AGAINST HUMAN PAPILLOMAVIRUS TYPE-16 GENITAL INFECTIONS

被引：22

作者：

CASON, J ^{[1
]}

KHAN, SA ^{[1
]}

BEST, JM ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMASS HOSP, RAYNE INST, DEPT IMMUNOL, LONDON SE1 7EH, ENGLAND

来源：

VACCINE | 1993年 / 11卷 / 06期

关键词：

HUMAN PAPILLOMAVIRUS TYPE-16; VACCINATION; CERVICAL CANCER;

D O I：

10.1016/0264-410X(93)90302-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human papillomavirus type-16 (HPV-16) is strongly associated with cervical carcinoma and cervical intra-epithelial neoplasia. It may soon be possible to develop prophylactic vaccines designed to induce neutralizing antibodies to HPV-16 virions in genital secretions and therapeutic vaccines to induce cytotoxic T-cell responses against HPV-16 early proteins in cervical intraepithelial neoplasia and cervical cancers. Although significant advances have been achieved, problems remain before such vaccines can be used routinely.

引用

页码：603 / 611

页数：9

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