SOME DIASTEREOSELECTIVE ENZYME-CATALYZED ESTERIFICATIONS AND INTERESTERIFICATIONS

被引：5

作者：

MACFARLANE, ELA ^{[1
]}

ROBERTS, SM ^{[1
]}

STEUKERS, VGR ^{[1
]}

TAYLOR, PL ^{[1
]}

机构：

[1] ICI PLC,PAINTS,RES DEPT,SLOUGH SL2 5DS,BERKS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 19期

关键词：

D O I：

10.1039/p19930002287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alcohol bicycloheptenol (+/-)-1 or the corresponding acetate (+/-)-5 couple with 2(p-chlorophenoxy)propionic acid (+/-)-2 using lipases in organic solvents to give the ester bicycloheptenyl 2-(p-chlorophenyl)propionate (R,R)-3 with good/excellent selectivity. Similarly, 2-methoxycyclohexanol (+/-)-6 or the corresponding acetate (+/-)-7 undergo enzyme-induced coupling to the acid (+/-)-2 to form the (R,R,R) -ester 2-methoxycyclohexyl p-chlorophenoxyacetate 8 almost exclusively in a doubly enantioselective process.

引用

页码：2287 / 2290

页数：4