IMMUNOLOGICAL RESPONSES OF BREAST-CANCER PATIENTS TO BEHAVIORAL INTERVENTIONS

被引：96

作者：

GRUBER, BL

HERSH, SP

HALL, NRS

WALETZKY, LR

KUNZ, JF

CARPENTER, JK

KVERNO, KS

WEISS, SM

机构：

[1] GEORGETOWN UNIV, MED CTR, DEPT PSYCHIAT & OBSTET & GYNECOL, WASHINGTON, DC 20007 USA

[2] GEORGE WASHINGTON UNIV, SCH MED, DEPT PSYCHIAT & PEDIAT, WASHINGTON, DC 20052 USA

[3] NCI, PEDIAT ONCOL BRANCH, BETHESDA, MD 20892 USA

[4] UNIV S FLORIDA, SCH MED, DEPT PSYCHIAT, TAMPA, FL 33620 USA

来源：

BIOFEEDBACK AND SELF-REGULATION | 1993年 / 18卷 / 01期

关键词：

BIOFEEDBACK (PSYCHOLOGY); BREAST NEOPLASMS; PSYCHONEUROIMMUNOLOGY; BEHAVIOR THERAPY; RELAXATION TECHNIQUES;

D O I：

10.1007/BF00999510

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

This article reports the results of an 18-month study of immune system and psychological changes in stage 1 breast cancer patients provided with relaxation, guided imagery, and biofeedback training. Thirteen lymph node negative patients who had recovered from a modified radical mastectomy were randomly assigned to either an immediate treatment or a delayed treatment control group. Multiple pre-post psychological measures were performed. Significant effects were found in natural killer cell (NK) activity (p < .017), mixed lymphocyte responsiveness (MLR) (p < .001), concanavalin A (Con-A) responsiveness (p < .001), and the number of peripheral blood lymphocytes (PBL) (p < .01). No significant psychological changes were detected; however, reductions were seen in psychological inventory scales measuring anxiety. The results show that behavioral interventions can be correlated with immune system measures, thereby replicating the results of an earlier pilot study from our Center. Discussion is provided on differential T-cell and B-cell responsiveness to behavioral interventions.

引用

页码：1 / 22

页数：22

共 37 条

[21]

HALL NR, 1983, IMMUNE MODULATION AG, P533

[22] A PSYCHO-BEHAVIORAL MODEL OF GENITAL HERPES RECURRENCE [J].

HOON, EF ;

HOON, PW ;

RAND, KH ;

JOHNSON, J ;

HALL, NR ;

EDWARDS, NB .

JOURNAL OF PSYCHOSOMATIC RESEARCH, 1991, 35 (01) :25-36

[23] RELAXATION, IMAGERY, AND NEUROIMMUNOMODULATION [J].

JASNOSKI, ML ;

KUGLER, J .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 496 :722-730

[24] PSYCHOSOCIAL ENHANCEMENT OF IMMUNOCOMPETENCE IN A GERIATRIC POPULATION [J].

KIECOLTGLASER, JK ;

GLASER, R ;

WILLIGER, D ;

STOUT, J ;

MESSICK, G ;

SHEPPARD, S ;

RICKER, D ;

ROMISHER, SC ;

BRINER, W ;

BONNELL, G ;

DONNERBERG, R .

HEALTH PSYCHOLOGY, 1985, 4 (01) :25-41

[25] MARITAL QUALITY, MARITAL DISRUPTION, AND IMMUNE FUNCTION [J].

KIECOLTGLASER, JK ;

FISHER, LD ;

OGROCKI, P ;

STOUT, JC ;

SPEICHER, CE ;

GLASER, R .

PSYCHOSOMATIC MEDICINE, 1987, 49 (01) :13-34

[26] PSYCHOSOCIAL MODIFIERS OF IMMUNOCOMPETENCE IN MEDICAL-STUDENTS [J].

KIECOLTGLASER, JK ;

GARNER, W ;

SPEICHER, C ;

PENN, GM ;

HOLLIDAY, J ;

GLASER, R .

PSYCHOSOMATIC MEDICINE, 1984, 46 (01) :7-14

[27] MECHANISM OF PLACEBO ANALGESIA [J].

LEVINE, JD ;

GORDON, NC ;

FIELDS, HL .

LANCET, 1978, 2 (8091) :654-657

[28] CORRELATION OF STRESS FACTORS WITH SUSTAINED DEPRESSION OF NATURAL-KILLER CELL-ACTIVITY AND PREDICTED PROGNOSIS IN PATIENTS WITH BREAST-CANCER [J].

LEVY, S ;

HERBERMAN, R ;

LIPPMAN, M ;

DANGELO, T .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (03) :348-353

[29] THE EFFECT OF BIOFEEDBACK-ASSISTED RELAXATION TRAINING ON BLOOD-PRESSURE AND SELECTED BIOCHEMICAL PARAMETERS IN PATIENTS WITH ESSENTIAL-HYPERTENSION [J].

MCGRADY, AV ;

YONKER, R ;

TAN, SY ;

FINE, TH ;

WOERNER, M .

BIOFEEDBACK AND SELF-REGULATION, 1981, 6 (03) :343-353

[30]

Miller R., 1981, SIMULTANEOUS STATIST

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