COEXPRESSION OF TGF-ALPHA, EPIDERMAL GROWTH-FACTOR RECEPTOR, AND P-GLYCOPROTEIN IN NORMAL AND BENIGN DISEASED BREAST TISSUES

被引：14

作者：

SCALA, S

SAEKI, T

LYNCH, A

SALOMON, D

MERINO, MJ

BATES, SE

机构：

[1] NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,BETHESDA,MD 20892

[2] NCI,TUMOR IMMUNOL & BIOL LAB,TUMOR GROWTH FACTOR SECT,BETHESDA,MD 20892

[3] NCI,PATHOL LAB,BETHESDA,MD 20892

来源：

DIAGNOSTIC MOLECULAR PATHOLOGY | 1995年 / 4卷 / 02期

关键词：

TGF-ALPHA; EGFR; P-GLYCOPROTEIN; BREAST TISSUE; IMMUNOSTAINING;

D O I：

10.1097/00019606-199506000-00010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-four normal or benign breast tissues were examined for the expression of transforming growth factor-alpha (TGF alpha), epidermal growth factor receptor (EGFR), and P-glycoprotein, the product of the mdr-1 gene. Specific staining for all three proteins was observed in the majority of the samples. P-glycoprotein staining was present in most (88%), and confined to the lumenal surface of the ductal epithelium. Membranous EGFR expression was observed in epithelial cells in 92% of the specimens and 42% displayed both myoepithelial and epithelial cell staining. TGF alpha staining was intense and uniformly distributed through the cytoplasm (96%). Coexpression of EGFR, TGF alpha, and P-glycoprotein in normal human breast tissues suggests a role for each of those proteins in normal breast physiology. An interaction may be present in normal breast tissue between the EGF receptor pathway and P-glycoprotein.

引用

页码：136 / 142

页数：7

共 28 条

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