INTRACELLULAR ANTIBODIES - DEVELOPMENT AND THERAPEUTIC POTENTIAL

被引：84

作者：

RICHARDSON, JH

MARASCO, WA

机构：

[1] Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0167-7799(00)88970-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Single-chain antibodies, synthesized by the cell and targeted to a particular cellular compartment, can be used to interfere in a highly specific manner with cell growth and metabolism. Recent applications of this technology include the phenotypic knockout of growth-factor receptors, the functional inactivation of p21(ras) and the inhibition of HIV-1 replication. Intracellular antibodies are likely to have a widespread impact in biological research as a simple and effective alternative to other forms of gene inactivation; they demonstrate clear potential as reagents for cancer therapy and for the control of infectious diseases.

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收藏

页码：306 / 310

页数：5

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