EFFECTS OF A M1 MUSCARINIC RECEPTOR AGONIST ON THE CENTRAL CHOLINERGIC SYSTEM, EVALUATED BY BRAIN MICRODIALYSIS

被引：27

作者：

OGANE, N ^{[1
]}

TAKADA, Y ^{[1
]}

IGA, Y ^{[1
]}

KAWANISHI, G ^{[1
]}

MIZOBE, F ^{[1
]}

机构：

[1] SNOW BRAND MILK PROD CO LTD,LIFE SCI RES INST,519 ISHIBASHI MACHI,TOCHIGI 32905,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 114卷 / 01期

关键词：

Acetylcholine content; AF102B; Brain dialysis; Endogenous acetylcholine release; FKS-508; M[!sub]1[!/sub] muscarinic receptor;

D O I：

10.1016/0304-3940(90)90434-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of a novel M1-receptor agonist, AF102B (FKS-508; cis-2-methylspiro(1,3-oxathiolane-5,3′)quinuclidine), on the central cholinergic system in vivo were evaluted by determination of acetylcholine (ACh) content in the rat brain after microwave irradiation and by measurement of ACh release with microdialysis perfusion in freely moving rats. Intraperitoneal administration of AF102B resulted in a significant decrease of ACh content in the brain, while AF102B produced an increase of in vivo ACh release. The present results suggest that ACh content in the brain after treatment with muscarinic agents may be related to the changes of ACh release, in which both M1 and M2 muscarinic receptors may be involved. © 1990.

引用

页码：95 / 100

页数：6

共 15 条

[1] AN INVIVO PHARMACOLOGICAL STUDY ON MUSCARINIC RECEPTOR SUBTYPES REGULATING CHOLINERGIC NEUROTRANSMISSION IN RAT STRIATUM [J].

CONSOLO, S ;

LADINSKY, H ;

VINCI, R ;

PALAZZI, E ;

WANG, JX .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (18) :3075-3077

[2] EFFECT OF CENTRAL STIMULANTS AND DEPRESSANTS ON MOUSE BRAIN ACETYLCHOLINE AND CHOLINE LEVELS [J].

CONSOLO, S ;

GARATTINI, S ;

LADINSKY, H ;

PERI, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1972, 18 (02) :251-+

[3] DETERMINATION OF ENDOGENOUS ACETYLCHOLINE-RELEASE IN FREELY MOVING RATS BY TRANSSTRIATAL DIALYSIS COUPLED TO A RADIOENZYMATIC ASSAY - EFFECT OF DRUGS [J].

CONSOLO, S ;

WU, CF ;

FIORENTINI, F ;

LADINSKY, H ;

VEZZANI, A .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (05) :1459-1465

[4]

COOPER JR, 1986, BIOCH BASIC NEUROPHA, P195

[5] BASAL ACETYLCHOLINE-RELEASE IN FREELY MOVING RATS DETECTED BY ONLINE TRANS-STRIATAL DIALYSIS - PHARMACOLOGICAL ASPECTS [J].

DAMSMA, G ;

WESTERINK, BHC ;

DEBOER, P ;

DEVRIES, JB ;

HORN, AS .

LIFE SCIENCES, 1988, 43 (14) :1161-1168

[6] (+/-)-CIS-2-METHYL-SPIRO(1,3-OXATHIOLANE-5,3')QUINUCLIDINE (AF102B) - A NEW M1 AGONIST ATTENUATES COGNITIVE DYSFUNCTIONS IN AF64A-TREATED RATS [J].

FISHER, A ;

BRANDEIS, R ;

PITTEL, Z ;

KARTON, I ;

SAPIR, M ;

DACHIR, S ;

LEVY, A ;

HELDMAN, E .

NEUROSCIENCE LETTERS, 1989, 102 (2-3) :325-331

[7] DUAL SYNAPTIC EFFECTS OF ACTIVATING M1-MUSCARINIC RECEPTORS, IN SUPERIOR CERVICAL-GANGLIA OF RABBITS [J].

MOCHIDA, S ;

MIZOBE, F ;

FISHER, A ;

KAWANISHI, G ;

KOBAYASHI, H .

BRAIN RESEARCH, 1988, 455 (01) :9-17

[8] AMELIORATION OF EXPERIMENTAL AMNESIA (PASSIVE-AVOIDANCE FAILURE) IN RODENTS BY THE SELECTIVE M1 AGONIST AF102B [J].

NAKAHARA, N ;

IGA, Y ;

MIZOBE, F ;

KAWANISHI, G .

JAPANESE JOURNAL OF PHARMACOLOGY, 1988, 48 (04) :502-505

[9] CENTRAL MUSCARINIC ACTIVITIES OF AN M1-SELECTIVE AGONIST - PREFERENTIAL EFFECT ON REVERSAL OF AMNESIA [J].

NAKAHARA, N ;

FUJISE, N ;

KAWANISHI, G ;

MIZOBE, F .

BRAIN RESEARCH, 1990, 507 (01) :172-175

[10] MUSCARINIC AUTORECEPTOR REGULATES ACETYLCHOLINE-RELEASE IN RAT HIPPOCAMPUS - INVITRO EVIDENCE [J].

NORDSTROM, O ;

BARTFAI, T .

ACTA PHYSIOLOGICA SCANDINAVICA, 1980, 108 (04) :347-353

← 1 2 →