LOWERED PLATELET GLUTATHIONE-PEROXIDASE ACTIVITY IN PATIENTS WITH INTRINSIC ASTHMA

被引：46

作者：

HASSELMARK, L ^{[1
]}

MALMGREN, R ^{[1
]}

UNGE, G ^{[1
]}

ZETTERSTROM, O ^{[1
]}

机构：

[1] KAROLINSKA HOSP,DEPT THORAC MED,S-10401 STOCKHOLM 60,SWEDEN

来源：

ALLERGY | 1990年 / 45卷 / 07期

关键词：

arachidonic acid; asthma; GSH‐Px; NSAID‐intolerance; platelets;

D O I：

10.1111/j.1398-9995.1990.tb00528.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Platelet glutathione peroxidase (GSH‐Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID‐intolerance. The mean value of GSH‐Px activity in the patients was 47.0±7.1 U/1011 platelets, which is significantly lower than that of 56.4±12 U/1011 platelets in the controls (P < 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH‐Px against oxidative stress and the tentative regulatory function of GSH‐Px in arachidonic acid metabolism. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：523 / 527

页数：5