EXPRESSION OF ALPHA-B-CRYSTALLIN IN THE DEVELOPING RAT-KIDNEY

被引：53

作者：

IWAKI, T ^{[1
]}

IWAKI, A ^{[1
]}

LIEM, RKH ^{[1
]}

GOLDMAN, JE ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PATHOL,630 W 168TH ST,NEW YORK,NY 10032

来源：

KIDNEY INTERNATIONAL | 1991年 / 40卷 / 01期

关键词：

D O I：

10.1038/ki.1991.178

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The expression and cellular localization of alpha-B-crystallin during rat renal development was studied by Northern blot analysis and by immunocytochemistry. Northern blotting of total RNA extracted from whole kidneys revealed that the messenger RNA for alpha-B-crystallin rapidly increased after birth to reach adult levels by 20 days. At the same time, immunohistochemistry for alpha-B-crystallin demonstrated that the prominent elongation of Henle's loop during the first 10 days of life was accompanied by increased alpha-B-crystallin expression. Thus, the development of alpha-B-crystallin expression is correlated temporally with the acquisition of tubule function in early post-natal life.

引用

页码：52 / 56

页数：5

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