FLUOXETINE AND TRIFLUOPERAZINE IN HUMAN BRAIN - A F-19-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY STUDY

被引:38
作者
KARSON, CN [1 ]
NEWTON, JEO [1 ]
MOHANAKRISHNAN, P [1 ]
SPRIGG, J [1 ]
KOMOROSKI, RA [1 ]
机构
[1] UNIV ARKANSAS MED SCI HOSP,LITTLE ROCK,AR 72205
关键词
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; F-19; PSYCHOPHARMACOLOGY; NEUROLEPTICS;
D O I
10.1016/0925-4927(92)90003-M
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Fluorine-19 (F-19) is a nonradioactive isotope that is well-suited to nuclear magnetic resonance spectroscopy (NMRS) and is a constituent of several medications used to treat psychiatric illnesses. Fluoxetine, a trifluorinated agent, generated a signal from brain that was readily measured by F-19-NMRS. Estimated brain concentrations ranged from 1.3-5.7 mug/ml in six subjects at a steady state dose of 40 mg/day. Enhanced sensitivity of F-19 has been obtained by conforming the surface coil to the shape of the forehead. Hence. at the current state of development, F-19-NMRS can be applied to clinical questions relevant to concentrations of fluoxetine in brain, We also report observation of NMRS signals from fluorinated neuroleptics in a number of patients at steady state. These signals continue to be difficult to obtain, although a correlation between dose and estimated brain concentrations is suggested.
引用
收藏
页码:95 / 104
页数:10
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