FLUOXETINE AND TRIFLUOPERAZINE IN HUMAN BRAIN - A F-19-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY STUDY

被引：38

作者：

KARSON, CN ^{[1
]}

NEWTON, JEO ^{[1
]}

MOHANAKRISHNAN, P ^{[1
]}

SPRIGG, J ^{[1
]}

KOMOROSKI, RA ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI HOSP,LITTLE ROCK,AR 72205

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1992年 / 45卷 / 02期

关键词：

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; F-19; PSYCHOPHARMACOLOGY; NEUROLEPTICS;

D O I：

10.1016/0925-4927(92)90003-M

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fluorine-19 (F-19) is a nonradioactive isotope that is well-suited to nuclear magnetic resonance spectroscopy (NMRS) and is a constituent of several medications used to treat psychiatric illnesses. Fluoxetine, a trifluorinated agent, generated a signal from brain that was readily measured by F-19-NMRS. Estimated brain concentrations ranged from 1.3-5.7 mug/ml in six subjects at a steady state dose of 40 mg/day. Enhanced sensitivity of F-19 has been obtained by conforming the surface coil to the shape of the forehead. Hence. at the current state of development, F-19-NMRS can be applied to clinical questions relevant to concentrations of fluoxetine in brain, We also report observation of NMRS signals from fluorinated neuroleptics in a number of patients at steady state. These signals continue to be difficult to obtain, although a correlation between dose and estimated brain concentrations is suggested.

引用

页码：95 / 104

页数：10