NEW ERA OF CALPAIN RESEARCH - DISCOVERY OF TISSUE-SPECIFIC CALPAINS

被引：170

作者：

SORIMACHI, H

SAIDO, TC

SUZUKI, K

机构：

[1] UNIV TOKYO, INST MOLEC & CELLULAR BIOSCI,DEPT MOLEC BIOL, MOLEC STRUCT & FUNCT LAB,BUNKYO KU, TOKYO 113, JAPAN

[2] TOKYO METROPOLITAN INST MED SCI, DEPT MOLEC BIOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

FEBS LETTERS | 1994年 / 343卷 / 01期

关键词：

CALPAIN; NOVEL SPECIES; MOLECULAR DIVERSITY; EVOLUTION; TISSUE-SPECIFIC EXPRESSION;

D O I：

10.1016/0014-5793(94)80595-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent discovery of several new calpain species other than the two species thus far studied reveals that calpain, especially the calpain large subunit, constitutes a family comprising at least six members that can be classified into ubiquitous (mu-, m- and mu/m-types) and tissue-specific (p94 or nCL-1 specific for skeletal muscle, and nCL-2 and -2' specific for stomach) calpains. The newly identified tissue-specific calpains have Various characteristics distinct from conventional calpains in structure, manner of expression, and enzyme activity. Unique features of tissuespecific calpains are discussed together with the evolutionary view of the calpain large subunit.

引用

页码：1 / 5

页数：5

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