MEDICAL PROGRESS - THE PRIMARY IMMUNODEFICIENCIES

被引：296

作者：

ROSEN, FS

COOPER, MD

WEDGWOOD, RJP

机构：

[1] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA

[2] UNIV ALABAMA,SCH MED,DEPT PEDIAT,BIRMINGHAM,AL

[3] UNIV WASHINGTON,SCH MED,DEPT PEDIAT,SEATTLE,WA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1995年 / 333卷 / 07期

关键词：

D O I：

10.1056/NEJM199508173330707

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The primary immunodeficiency disorders reflect abnormalities in the development and maturation of cells of the immune system. These defects result in an increased susceptibility to infection; recurrent pyogenic infections occur with defects of humoral immunity, and opportunistic infections with defects of cell-mediated immunity. These two broad categories of illness correspond roughly to defects in the two principal types of immunocompetent cells, B lymphocytes and T lymphocytes. Defective development of B cells results in abnormalities in humoral immunity, whereas defects in the development of T cells cause problems with cellular immunity. When pathogens are taken up by macrophages or dendritic cells,.Â .Â . © 1995, Massachusetts Medical Society. All rights reserved.

引用

页码：431 / 440

页数：10

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