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THE 8-HYDROXYGUANINE CONTENT OF ISOLATED-MITOCHONDRIA INCREASES WITH LIPID-PEROXIDATION

被引：56
作者：
HRUSZKEWYCZ, AM
BERGTOLD, DS
机构：
[1] NATL INST STAND & TECHNOL,CTR RADIAT RES,GAITHERSBURG,MD 20899
[2] GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20037
来源：
MUTATION RESEARCH | 1990年 / 244卷 / 02期
关键词：
8-Hydroxyguanine; DNA damage; Lipid peroxidation; Mitochondria; Mitochondrial DNA;
D O I：
10.1016/0165-7992(90)90060-W
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
When lipid peroxidation was induced in isolated mitochondria there was a marked increase in the 8-hydroxyguanine content of the nucleic acids extracted from these mitochondria. The elevation of 8-hydroxyguanine levels was associated with an extensive alteration of normal electrophoretic mobility of mitochondrial DNA. However, suppression of lipid peroxidation with α-tocopherol proportionally attenuated 8-hydroxyguanine production and limited the electrophoretic mobility change of mitochondrial DNA. © 1990.
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页码：123 / 128
页数：6
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