SOLID-PHASE SYNTHESIS OF 5',3'-BIFUNCTIONAL OLIGODEOXYRIBONUCLEOTIDES BEARING A MASKED THIOL-GROUP AT THE 3'-END

被引：25

作者：

BONFILS, E

THUONG, NT

机构：

[1] Centre de Biophysique Moléculaire. C.N.R.S., 45071 Orléans cédex 2, 1A, avenue la Recherche Scientifique

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 26期

关键词：

BIFUNCTIONAL OLIGONUCLEOTIDES; SOLID PHASE SYNTHESIS; 3'-THIOL; 5'-THIOPHOSPHATE; 5'-ACRIDINE;

D O I：

10.1016/0040-4039(91)80686-Z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Immobilization of the ''disulfide arm'' 8 on a solid support via a succinyl linkage allows the automated synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3'-end and other modifications at the 5'-end.

引用

页码：3053 / 3056

页数：4

共 8 条

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