TAILOR-MADE HOST FOR PIPERAZINE AND RELATED AMINES

被引：6

作者：

HOSS, R ^{[1
]}

VOGTLE, F ^{[1
]}

机构：

[1] UNIV BONN,INST ORGAN CHEM & BIOCHEM,GERHARD DOMAGK STR 1,W-5300 BONN 1,GERMANY

来源：

CHEMISCHE BERICHTE-RECUEIL | 1993年 / 126卷 / 04期

关键词：

DIAMINE; HOST-GUEST CHEMISTRY; MACROCYCLE; SUPRAMOLECULAR CHEMISTRY; RECEPTOR MOLECULE; SYNTHETIC;

D O I：

10.1002/cber.19931260421

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 38-membered bis-catechol 4b is obtained by cyclisation of the diacyl dichloride 3c with the diamine 2b in 45% yield, whereas a 68-membered octalactam 7 is formed under similar conditions from 5 and 1b. Bis-catechol 4b is a selective host compound for piperazine (8) and the structurally related diamine 9. Association constants for the 1:1 complexes have been measured by H-1-NMR titration experiments. A nucleo-base guest (pterine, 24) was extracted into a hydrochloric acid phase by complex formation with the host 4b. The results are compared with solubility and transport experiments obtained by use of analogous macrobicyclic tris-catechol hosts.

引用

页码：1003 / 1009

页数：7