ALCOHOL METABOLISM - ROLE OF MICROSOMAL OXIDATION IN VIVO

被引：62

作者：

TEPHLY, TR

TINELLI, F

WATKINS, WD

机构：

[1] Department of Pharmacology, University of Michigan Medical School, Ann Arbor

来源：

SCIENCE | 1969年 / 166卷 / 3905期

关键词：

D O I：

10.1126/science.166.3905.627

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.

引用

页码：627 / &

共 13 条

[1]

GILLETTE JR, 1957, J PHARMACOL EXP THER, V119, P532

[2]

LESTER D, 1968, Q J STUD ALCOHOL, V29, P449

[3] ETHANOL OXIDATION BY HEPATIC MICROSOMES - ADAPTIVE INCREASE AFTER ETHANOL FEEDING [J].