CONFORMATION AND IMMUNOGENICITY OF ENGINEERED REPEATING SEGMENT OF THE CIRCUMSPOROZOITE SURFACE PROTEIN OF PLASMODIUM-FALCIPARUM

被引：8

作者：

ARMAH, GE

NISHIKAWA, S

MIKI, S

OMATA, Y

NAKABAYASHI, T

TOMITA, K

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,1-6 YAMADAOKA,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,MICROBIAL DIS RES INST,OSAKA,JAPAN

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 38卷 / 01期

关键词：

Conformation; Immunogenicity; Malaria vaccine; Plasmodium falciparum; Tetrapeptide;

D O I：

10.1016/0166-6851(90)90213-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide vaccines based on units of the immunodominant tetrapeptide repeats, Asn-Ala-Asn-Pro and Asn-Val-Asp-Pro, of the circumsporozoite surface protein of the parasite Plasmodium falciparum are presently being developed as potential malaria vaccines. The N-terminal fusion of a hydrophobic protein to units of the tetrapeptide repeat affected the immunogenicity and conformational stability of the peptide, and also induced a secondary structure in the peptide. Peptide antigenicity, as well as conformational stability, was significantly increased. © 1990.

引用

页码：135 / 140

页数：6

共 16 条

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