IMPAIRMENT IN MITOCHONDRIAL CYTOCHROME-OXIDASE GENE-EXPRESSION IN ALZHEIMER-DISEASE

被引：176

作者：

CHANDRASEKARAN, K

GIORDANO, T

BRADY, DR

STOLL, J

MARTIN, LJ

RAPOPORT, SI

机构：

[1] ABBOTT LABS,DEPT 47-W,ABBOTT PK,IL 60064

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 24卷 / 1-4期

关键词：

HUMAN BRAIN; TEMPORAL CORTEX; PRIMARY MOTOR CORTEX; NORTHERN BLOT; OXIDATIVE METABOLISM; ALZHEIMERS DISEASE; SYNAPTIC LOSS;

D O I：

10.1016/0169-328X(94)90147-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.

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页码：336 / 340

页数：5

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