THE EFFECTS OF LACTIC-ACID ON PGE(2) PRODUCTION BY MACROPHAGES AND HUMAN SYNOVIAL FIBROBLASTS - A POSSIBLE EXPLANATION FOR PROBLEMS ASSOCIATED WITH THE DEGRADATION OF POLY(LACTIDE) IMPLANTS

被引：11

作者：

DAWES, E ^{[1
]}

RUSHTON, N ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,ORTHOPAED RES UNIT,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

CLINICAL MATERIALS | 1994年 / 17卷 / 04期

关键词：

D O I：

10.1016/0267-6605(94)90031-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of this study was to investigate the effects of lactic acid on cells found at the bone-implant interface in order to try to discover more about the effects of degradation of implants manufactured from poly(lactide). This study shows that human synovial fibroblasts and murine macrophages release prostaglandin E(2) (PGE(2)) a bone resorbing and inflammatory mediator, into the surrounding medium when exposed to lactic acid. The production of PGE(2) in response to lactate may help to explain isolated cases of inflammation and discomfort seen some time after fracture fixation with poly(lactide) implants.

引用

页码：157 / 163

页数：7

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