CATALYTIC ANTIBODIES

被引:21
作者
HILVERT, D [1 ]
机构
[1] SCRIPPS RES INST, DEPT BIOL MOLEC, LA JOLLA, CA 92037 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0959-440X(94)90226-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The development of catalytic antibodies for a wide range of chemical transformations represents one of the most promising and versatile approaches to the problem of enzyme engineering to emerge in the last several years. Recent advances in the production and characterization of these agents are discussed.
引用
收藏
页码:612 / 617
页数:6
相关论文
共 37 条
  • [1] BINDING OF A HIGH-ENERGY SUBSTRATE CONFORMER IN ANTIBODY CATALYSIS
    CAMPBELL, AP
    TARASOW, TM
    MASSEFSKI, W
    WRIGHT, PE
    HILVERT, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) : 8663 - 8667
  • [2] CAMPBELL DA, 1994, J AM CHEM SOC, V116, P216
  • [3] CATALYTIC ANTIBODIES FROM COMBINATORIAL LIBRARIES
    CHEN, YCJ
    DANON, T
    SASTRY, L
    MUBARAKI, M
    JANDA, KD
    LERNER, RA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (01) : 357 - 358
  • [4] CRYSTAL-STRUCTURES OF THE MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS-SUBTILIS AND ITS COMPLEX WITH A TRANSITION-STATE ANALOG
    CHOOK, YM
    KE, HM
    LIPSCOMB, WN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) : 8600 - 8603
  • [5] CATALYTIC ANTIBODY-ACTIVITY ELICITED BY ACTIVE IMMUNIZATION - EVIDENCE FOR NATURAL VARIATION INVOLVING PREFERENTIAL STABILIZATION OF THE TRANSITION-STATE
    GALLACHER, G
    JACKSON, CS
    SEARCEY, M
    GOEL, R
    MELLOR, GW
    SMITH, CZ
    BROCKLEHURST, K
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 214 (01): : 197 - 207
  • [6] Garrard Lisa J., 1992, Current Opinion in Biotechnology, V3, P474, DOI 10.1016/0958-1669(92)90074-S
  • [7] SUBSTITUENT EFFECTS ON AN ANTIBODY-CATALYZED HYDROLYSIS OF PHENYL-ESTERS - FURTHER EVIDENCE FOR AN ACYL-ANTIBODY INTERMEDIATE
    GIBBS, RA
    BENKOVIC, PA
    JANDA, KD
    LERNER, RA
    BENKOVIC, SJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (09) : 3528 - 3534
  • [8] CRYSTAL-STRUCTURE OF A CATALYTIC ANTIBODY FAB WITH ESTERASE-LIKE ACTIVITY
    GOLINELLIPIMPANEAU, B
    GIGANT, B
    BIZEBARD, T
    NAVAZA, J
    SALUDJIAN, P
    ZEMEL, R
    TAWFIK, DS
    ESHHAR, Z
    GREEN, BS
    KNOSSOW, M
    [J]. STRUCTURE, 1994, 2 (03) : 175 - 183
  • [9] CONTROL OF THE EXO-PATHWAY AND ENDO-PATHWAY OF THE DIELS-ALDER REACTION BY ANTIBODY CATALYSIS
    GOUVERNEUR, VE
    HOUK, KN
    DEPASCUALTERESA, B
    BENO, B
    JANDA, KD
    LERNER, RA
    [J]. SCIENCE, 1993, 262 (5131) : 204 - 208
  • [10] MONOFUNCTIONAL CHORISMATE MUTASE FROM BACILLUS-SUBTILIS - KINETIC AND C-13 NMR-STUDIES ON THE INTERACTIONS OF THE ENZYME WITH ITS LIGANDS
    GRAY, JV
    EREN, D
    KNOWLES, JR
    [J]. BIOCHEMISTRY, 1990, 29 (37) : 8872 - 8878