A DOSE-RESPONSE STUDY OF DEXTRORPHAN IN PERMANENT FOCAL ISCHEMIA

被引：16

作者：

GRAHAM, SH

CHEN, J

SIMON, RP

机构：

[1] VET ADM MED CTR,DEPT NEUROL,SAN FRANCISCO,CA 94121

[2] SAN FRANCISCO GEN HOSP,DEPT NEUROL,SAN FRANCISCO,CA 94110

来源：

NEUROSCIENCE LETTERS | 1993年 / 160卷 / 01期

关键词：

ISCHEMIA; EXCITATORY AMINO ACID; DEXTRORPHAN; NMDA; STROKE; NEUROPROTECTION;

D O I：

10.1016/0304-3940(93)90907-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The dose-response curve and time window of efficacy for dextrorphan in permanent focal brain ischemia leading to infarction was studied in the rat. With pretreatment, the maximum effective dose of 20 mg/kg reduced the eventual infarct volume by greater than 50%. Delayed drug administration, up to 45 min following permanent middle cerebral artery occlusion. significantly reduced infarct size.

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页码：21 / 23

页数：3

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