A 2ND THROMBOSPONDIN GENE IN THE MOUSE IS SIMILAR IN ORGANIZATION TO THROMBOSPONDIN-1 BUT DOES NOT RESPOND TO SERUM

被引：69

作者：

BORNSTEIN, P ^{[1
]}

DEVARAYALU, S ^{[1
]}

LI, P ^{[1
]}

DISTECHE, CM ^{[1
]}

FRAMSON, P ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 19期

关键词：

DNA SEQUENCE; EXON INTRON STRUCTURE; PROTEIN HOMOLOGY; CHROMOSOME-17; BAND-A3;

D O I：

10.1073/pnas.88.19.8636

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A second, expressed thrombospondin (TSP) gene, Thbs2, has been identified in the mouse. The exon/intron organization of Thbs2 is highly conserved in comparison with Thbs1 in that exon size and the pattern of interruption of the reading frame by introns are preserved, but there is a marked divergence in coding sequence, primarily in the first 7 exons. On the other hand, the DNA and translated amino acid sequences of exons coding for the type I, II, and III repeats in the two TSPs are far better conserved. Thbs2 is located on chromosome 17, band A3, whereas Thbs1 was found on chromosome 2, band F. In marked contrast to Thbs1, the Thbs2 gene is not induced by serum in NIH 3T3 cells; promoter sequences in the two genes are also very different. It is therefore likely that the two TSPs perform related but distinct functions.

引用

页码：8636 / 8640

页数：5

共 39 条

[21] PLATELET-DERIVED GROWTH-FACTOR AND HEPARIN-LIKE GLYCOSAMINOGLYCANS REGULATE THROMBOSPONDIN SYNTHESIS AND DEPOSITION IN THE MATRIX BY SMOOTH-MUSCLE CELLS [J].