INTERFERONS - PLEIOTROPIC CELLULAR MODULATORS

被引：38

作者：

BORDEN, EC

机构：

[1] MED COLL WISCONSIN,DEPT MED,MILWAUKEE,WI 53226

[2] MED COLL WISCONSIN,DEPT MICROBIOL,MILWAUKEE,WI 53226

[3] MED COLL WISCONSIN,DEPT PEDIAT,MILWAUKEE,WI 53226

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 62卷 / 01期

关键词：

D O I：

10.1016/0090-1229(92)90037-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferons play a key role in host response as pleiotropic modulators of cell function. As induced proteins, interferons contrast with other physiologic regulators such as glucocorticoids which are produced relatively continuously. Antitumor effects have been suggested to be principally the result of two mechanisms: a direct effect on the functional capacity or antigenic composition of tumor cells or an indirect effect on modulation of immunological effector cell populations with tumor specificities. Over the past decade, interferons have been established as therapeutically useful molecules for malignant and viral diseases. © 1992.

引用

页码：S18 / S24

页数：7

共 89 条

[1] ANTIGENIC STRUCTURE OF HUMAN INTERFERON-RHO-1 (INTERFERON-ALPHA-2-1) - COMPARISON WITH OTHER HUMAN INTERFERONS [J].