INTERFERONS - PLEIOTROPIC CELLULAR MODULATORS

被引：38

作者：

BORDEN, EC

机构：

[1] MED COLL WISCONSIN,DEPT MED,MILWAUKEE,WI 53226

[2] MED COLL WISCONSIN,DEPT MICROBIOL,MILWAUKEE,WI 53226

[3] MED COLL WISCONSIN,DEPT PEDIAT,MILWAUKEE,WI 53226

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 62卷 / 01期

关键词：

D O I：

10.1016/0090-1229(92)90037-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferons play a key role in host response as pleiotropic modulators of cell function. As induced proteins, interferons contrast with other physiologic regulators such as glucocorticoids which are produced relatively continuously. Antitumor effects have been suggested to be principally the result of two mechanisms: a direct effect on the functional capacity or antigenic composition of tumor cells or an indirect effect on modulation of immunological effector cell populations with tumor specificities. Over the past decade, interferons have been established as therapeutically useful molecules for malignant and viral diseases. © 1992.

引用

收藏

页码：S18 / S24

页数：7

相关论文

共 89 条

[41]

KROWN SE, 1986, SEMIN ONCOL, V13, P207

[42]

KROWN SE, 1989, J INTERFERON RES, V9, pS117

[43] INHIBITION OF INTERFERON-GAMMA MAY SUPPRESS ALLOGRAFT REACTIVITY BY LYMPHOCYTES-T-INVITRO AND INVIVO [J].

LANDOLFO, S ;

COFANO, F ;

GIOVARELLI, M ;

PRAT, M ;

CAVALLO, G ;

FORNI, G .

SCIENCE, 1985, 229 (4709) :176-179

[44] INTERFERON INHIBITS THE ESTABLISHMENT OF COMPETENCE IN GO/S-PHASE TRANSITION [J].

LIN, SL ;

KIKUCHI, T ;

PLEDGER, WJ ;

TAMM, I .

SCIENCE, 1986, 233 (4761) :356-359

[45] THE DETERMINATION OF AN IMMUNOLOGICALLY ACTIVE DOSE OF INTERFERON-GAMMA IN PATIENTS WITH MELANOMA [J].

MALUISH, AE ;

URBA, WJ ;

LONGO, DL ;

OVERTON, WR ;

COGGIN, D ;

CRISP, ER ;

WILLIAMS, R ;

SHERWIN, SA ;

GORDON, K ;

STEIS, RG .

JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (03) :434-445

[46] MEASUREMENT OF 2',5'-OLIGOADENYLATE SYNTHETASE IN PATIENTS RECEIVING INTERFERON-ALPHA [J].

MERRITT, JA ;

BORDEN, EC ;

BALL, LA .

JOURNAL OF INTERFERON RESEARCH, 1985, 5 (01) :191-198

[47] MODULATION OF 2',5'-OLIGOADENYLATE SYNTHETASE IN PATIENTS TREATED WITH ALPHA-INTERFERON - EFFECTS OF DOSE, SCHEDULE, AND ROUTE OF ADMINISTRATION [J].

MERRITT, JA ;

BALL, LA ;

SIELAFF, KM ;

MELTZER, DM ;

BORDEN, EC .

JOURNAL OF INTERFERON RESEARCH, 1986, 6 (03) :189-198

[48] ADMINISTRATION OF RECOMBINANT INTERFERON-GAMMA TO CANCER-PATIENTS ENHANCES MONOCYTE SECRETION OF HYDROGEN-PEROXIDE [J].

NATHAN, CF ;

HOROWITZ, CR ;

DELAHARPE, J ;

VADHANRAJ, S ;

SHERWIN, SA ;

OETTGEN, HF ;

KROWN, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8686-8690

[49] INTERFERONS - BIOLOGICAL AND CLINICAL EFFECTS [J].

NELSON, BE ;

BORDEN, EC .

SEMINARS IN SURGICAL ONCOLOGY, 1989, 5 (06) :391-401

[50] ULTRASTRUCTURAL EFFECTS OF RECOMBINANT GAMMA-INTERFERON ON CULTURED HUMAN KERATINOCYTES [J].

NICKOLOFF, BJ ;

MAHRLE, G ;

MORHENN, V .

ULTRASTRUCTURAL PATHOLOGY, 1986, 10 (01) :17-21

← 1 2 3 4 5 6 7 8 9 →