DOES OMEPRAZOLE (PRILOSEC) IMPROVE RESPIRATORY-FUNCTION IN ASTHMATICS WITH GASTROESOPHAGEAL REFLUX - A DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER STUDY

被引：113

作者：

MEIER, JH

MCNALLY, PR

PUNJA, M

FREEMAN, SR

SUDDUTH, RH

STOCKER, N

PERRY, M

SPAULDING, HS

机构：

[1] FITZSIMONS ARMY MED CTR,DEPT MED,AURORA,CO 80045

[2] FITZSIMONS ARMY MED CTR,GASTROENTEROL SERV,AURORA,CO 80045

[3] FITZSIMONS ARMY MED CTR,ALLERGY IMMUNOL SERV,AURORA,CO 80045

[4] FITZSIMONS ARMY MED CTR,DEPT PHARMACOL,AURORA,CO 80045

[5] FITZSIMONS ARMY MED CTR,DEPT PULM,AURORA,CO 80045

来源：

DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 10期

关键词：

ASTHMA; GASTROESOPHAGEAL REFLUX; ESOPHAGITIS; OMEPRAZOLE;

D O I：

10.1007/BF02090360

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastroesophageal reflux (GER) is common among patients with asthma, and it has been speculated that high GER may exacerbate asthma in some. This study was designed to determine if suppression of acid reflux in patients with asthma would improve pulmonary function. A double-blind, placebo-controlled crossover study design was used to determine the effect of GER suppression with omeprazole (20 mg twice daily) on pulmonary function among asthmatic patients with esophagitis. Four of 15 (27%) asthma patients with GER were shown to have a greater than or equal to 20% net improvement in pulmonary function (FEV(1)) after treatment for six weeks with omeprazole. These results indicate that some patients with asthma and GER will have improved pulmonary function when acid GER is treated with omeprazole.

引用

页码：2127 / 2133

页数：7

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