NITROGEN REGULATION IN FUNGI

被引：67

作者：

CADDICK, MX

PETERS, D

PLATT, A

机构：

[1] Department of Genetics and Microbiology, Donnan Laboratories, University of Liverpool, Liverpool, L69 3BX

来源：

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 1994年 / 65卷 / 03期

关键词：

AREA; ASPERGILLUS NIDULANS; GATA-1; NIT-2; NITROGEN METABOLITE REPRESSION; NEUROSPORA CRASSA;

D O I：

10.1007/BF00871943

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nitrogen regulation has been extensively studied in fungi revealing a complex array of interacting regulatory genes. The general characterisation of the systems in Aspergillus nidulans and Neurospora crassa shall be briefly described, but much of this paper will concentrate specifically on the recent molecular characterisation of areA, the principle regulatory gene from A. nidulans which mediates nitrogen metabolite repression. Three areas shall be explored in detail, firstly the DNA binding domain, which has been characterised extensively by both molecular and genetic analysis. Secondly we shall report recent analysis which has revealed the presence of related DNA binding activities in A. nidulans. Finally we shall discuss the mechanism by which the nitrogen state of the cell is monitored by the areA product, in particular localisation of the domain within the areA product which mediates the regulatory response within the protein.

引用

页码：169 / 177

页数：9

共 66 条

[21] REGULATORY CIRCUIT FOR RESPONSES OF NITROGEN CATABOLIC GENE-EXPRESSION TO THE GLN3-PROTEIN AND DAL80-PROTEIN AND NITROGEN CATABOLITE REPRESSION IN SACCHAROMYCES-CEREVISIAE [J].