DYNEMICINS, NEW ANTIBIOTICS WITH THE 1,5-DIYN-3-ENE AND ANTHRAQUINONE SUBUNIT .1. PRODUCTION, ISOLATION AND PHYSICOCHEMICAL PROPERTIES

被引：29

作者：

KONISHI, M

OHKUMA, H

MATSUMOTO, K

SAITOH, K

MIYAKI, T

OKI, T

KAWAGUCHI, H

机构：

[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 12期

关键词：

D O I：

10.7164/antibiotics.44.1300

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dynemicin A, a novel antibiotic containing the bicyclo[7.3.1]-1,5-diyn-3-ene and 1,4,6-trihydroxyanthraquinone functionalities, was isolated from the culture broth of Micromonospora chersina sp. nov. M956-1. The antibiotic exhibited potent in vitro antibacterial and cytotoxic activity, and in in vivo, it cured mice from lethal Staphylococcus aureus infection and prolonged survival time of mice inoculated with murine tumors. Three satellite components, dynemicins L, M and N, were also isolated from the culture broth and chemically characterized.

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页码：1300 / 1305

页数：6

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