DYNEMICINS, NEW ANTIBIOTICS WITH THE 1,5-DIYN-3-ENE AND ANTHRAQUINONE SUBUNIT .2. ANTITUMOR-ACTIVITY OF DYNEMICIN-A AND ITS TRIACETYL DERIVATIVE

被引：18

作者：

KAMEI, H

NISHIYAMA, Y

TAKAHASHI, A

OBI, Y

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 12期

关键词：

D O I：

10.7164/antibiotics.44.1306

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dynemicin A showed extremely potent in vitro cytotoxicity against a variety of murine and human tumor cells. In the experimental animal tumor models implanted ip with P388, L1210 leukemias and B16 melanoma cells. dynemicin A administered ip significantly prolonged life-span of tumor-bearing mice with the wide range of activity. This antibiotic administered iv was also active against iv implanted P388 and L1210 leukemias. In the macromolecule biosynthesis of B16 melanoma cells, dynemicin A inhibited DNA synthesis specifically. The triacetyl derivative exhibited similar in vitro and in vivo antitumor activities to those of the parent antibiotic.

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页码：1306 / 1311

页数：6

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