FIRST ENANTIOSELECTIVE SYNTHESIS OF (-)-AKAGERINE BY A CHEMOENZYMATIC APPROACH

被引：25

作者：

DANIELI, B ^{[1
]}

LESMA, G ^{[1
]}

MAURO, M ^{[1
]}

PALMISANO, G ^{[1
]}

PASSARELLA, D ^{[1
]}

机构：

[1] UNIV MILAN,CNR,CTR STUDIO SOSTANZE ORGAN NAT,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 08期

关键词：

D O I：

10.1021/jo00113a034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Akagerine (1) was synthesized in an efficient and stereocontrolled fashion from the readily available (1S,2R)-cyclohexenedimethanol monoacetate 4. Key steps were the cleavage of the C(17)/C(18) bond of 14a and the regio- and stereoselective cyclization of the dialdehyde 16 to give the tetracyclic skeleton of akagerine.

引用

页码：2506 / 2513

页数：8

共 36 条

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