TRANSMISSION OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS IN FAMILIES OF ADULT PERIODONTITIS PATIENTS

被引:56
作者
PETIT, MDA [1 ]
VANSTEENBERGEN, TJM [1 ]
DEGRAAFF, J [1 ]
VANDERVELDEN, U [1 ]
机构
[1] ACAD CTR DENT AMSTERDAM,DEPT ORAL MICROBIOL,1066 EA AMSTERDAM,NETHERLANDS
关键词
A-ACTINOMYCETEMCOMITANS; PERIODONTITIS; TRANSMISSION; FAMILIES;
D O I
10.1111/j.1600-0765.1993.tb01077.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
At present Actinobacillus actinomycetemcomitans is regarded as an important microorganism in the etiology of some forms of periodontitis. The purpose of the present investigation was to study the number of Restriction Endonuclease Analysis (REA)-types present in the oral cavity of A. actinomycetemcomitans positive subjects and to study the possibility of transmission of A. actinomycetemcomitans within families of adult periodontitis patients. DNA of A. actinomycetemcomitans isolates was digested with a combination of the restriction endonucleases PstI and BamHI, after which the DNA fragments were separated by agarose gelelectrophoresis. To study the number of REA-types, multiple A. actinomycetemcomitans isolates obtained from 8 different sites in the oral cavity of five subjects were typed. The results showed that in most cases only one REA-type is present. In the 13 families investigated in 4 of the 26 children (15%) and in 1 of the 13 spouses (8%) of the adult periodontitis patients an indistinguishable REA-type was found within the families. This suggests that also in the case of adult periodontitis transmission of A. actinomycetemcomitans is possible, but does not seem to occur easily.
引用
收藏
页码:335 / 345
页数:11
相关论文
共 34 条
[1]   INTRAFAMILIAL TRANSMISSION OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS [J].
ALALUUSUA, S ;
ASIKAINEN, S ;
LAI, CH .
JOURNAL OF PERIODONTOLOGY, 1991, 62 (03) :207-210
[2]   RECOVERY OF A-ACTINOMYCETEMCOMITANS FROM TEETH, TONGUE, AND SALIVA [J].
ASIKAINEN, S ;
ALALUUSUA, S ;
SAXEN, L .
JOURNAL OF PERIODONTOLOGY, 1991, 62 (03) :203-206
[3]   SUBGINGIVAL MICROFLORA AND PERIODONTAL CONDITIONS IN HEALTHY TEENAGERS [J].
ASIKAINEN, S ;
ALALUUSUA, S ;
KARI, K ;
KLEEMOLAKUJALA, E .
JOURNAL OF PERIODONTOLOGY, 1986, 57 (08) :505-509
[4]   DISTRIBUTION OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS SEROTYPES IN PERIODONTAL HEALTH AND DISEASE [J].
ASIKAINEN, S ;
LAI, CH ;
ALALUUSUA, S ;
SLOTS, J .
ORAL MICROBIOLOGY AND IMMUNOLOGY, 1991, 6 (02) :115-118
[5]  
BEATY TH, 1987, AM J HUM GENET, V40, P443
[6]   PROBLEMS OF GENETIC MODEL TESTING IN EARLY ONSET PERIODONTITIS [J].
BOUGHMAN, JA ;
BEATY, TH ;
YANG, P ;
GOODMAN, SB ;
WOOTEN, RK ;
SUZUKI, JB .
JOURNAL OF PERIODONTOLOGY, 1988, 59 (05) :332-337
[7]  
CHUNG HJ, 1989, J PERIODONTOL, V60, P509
[8]   GENETIC APPROACH TO THE STUDY OF EPIDEMIOLOGY AND PATHOGENESIS OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS IN LOCALIZED JUVENILE PERIODONTITIS [J].
DIRIENZO, JM ;
SLOTS, J .
ARCHIVES OF ORAL BIOLOGY, 1990, 35 :S79-S84
[9]  
DIRIENZO JM, 1991, PERIODONTAL DISEASE, P379
[10]   MICROBIOLOGICAL STUDY OF LOCALIZED JUVENILE PERIODONTITIS IN PANAMA [J].
EISENMANN, AC ;
EISENMANN, R ;
SOUSA, O ;
SLOTS, J .
JOURNAL OF PERIODONTOLOGY, 1983, 54 (12) :712-713