SYNTHESIS AND RADIOPHARMACOLOGICAL STUDY OF NEW METALATED THIAZOLIDINES AND DITHIOACETALS OF N-ALLYL-SUBSTITUTED CYSTEAMINE AND METHYLCYSTEAMINE

被引：5

作者：

RIMA, G

SATGE, J

SENTENACROUMANOU, H

FATOME, M

LAVAL, JD

LION, C

ALAZARD, O

CHABERTIER, P

机构：

[1] DIRECT RECH ETUDES & TECH,F-00460 ARMEES,FRANCE

[2] CTR RECH SERV SANTE ARMEES,DIV RADIOBIOL & RADIOPROTECT,F-38702 LA TRONCHE,FRANCE

[3] UNIV PARIS 07,INST TOPOL & DYNAM SYST,CNRS,F-75221 PARIS 05,FRANCE

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1994年 / 8卷 / 05期

关键词：

GERMA- AND SILATHIAZOLIDINES; GERMA- AND SILADITHIOACETALS; TOXICITY; N-ALLYLCYSTEAMINE; N-ALLYMETHYLCYSTEAMINE; RADIOPROTECTIVE ACTIVITY;

D O I：

10.1002/aoc.590080508

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

New germa- and silathiazolidines or germa- and siladithioacetals with N-allyl-substituted cysteamine and methylcysteamine ligands have been synthesized and their pharmacological properties (toxicity, radioprotective activity) have been studied. A notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new organometallic derivatives compared to N-allyl-substituted cysteamine and methylcysteamine were observed.

引用

页码：481 / 490

页数：10

共 22 条

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[2]

DOUSSE G, 1973, SYNTH INORG METALORG, V3, P11

[3]

FATOME M, 1984, EUR J MED CHEM, V19, P119

[4] STUDY OF GERMATHIAZOLIDINES AND GERMYLATED DITHIOACETALS DERIVED FROM N-SUBSTITUTED CYSTEAMINE AND METHYLCYSTEAMINE - SYNTHESIS AND RADIOPROTECTIVE ACTIVITY [J].