FAMILIAL OCCURRENCE OF GASTROSCHISIS - 4 NEW CASES AND REVIEW OF THE LITERATURE

被引:45
作者
SALINAS, CF
BARTOSHESKY, L
OTHERSEN, HB
LEAPE, L
FEINGOLD, M
JORGENSON, RJ
机构
[1] MED UNIV S CAROLINA,COLL MED,DEPT SURG,CHARLESTON,SC 29403
[2] TUFTS UNIV,NEW ENGLAND MED CTR,CTR GENET COUNSELING & BIRTH DEFECTS,BOSTON,MA 02111
[3] TUFTS UNIV,NEW ENGLAND MED CTR,DIV PEDIAT SURG,BOSTON,MA 02111
来源
AMERICAN JOURNAL OF DISEASES OF CHILDREN | 1979年 / 133卷 / 05期
关键词
D O I
10.1001/archpedi.1979.02130050058011
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In two unrelated families, there was familial occurrence of gastroschisis. In one family, a boy and girl were affected and there was a family history of stillbirth, abortion, prematurity, and esophageal obstruction. In the second family, two boys were affected and there was a family history of spontaneous abortion, inguinal hernia, and umbilical hernia. The recurrence of gastroschisis, generally considered a sporadic congenital effect, suggests that the condition may be genetic in nature. Furthermore, the pedigree of one of the families suggests that gastroschisis may be a severe expression of umbilical hernia or other abdominal wall defects. Autosomal dominant inheritance with variable expressivity or multifactorial inheritance may explain the occurrence of gastroschisis in the two families. Thus, a family history of abdominal wall defects may increase the risk for gastroschisis. (Am J Dis Child 133:514-517, 1979. © 1979, American Medical Association. All rights reserved.
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页码:514 / 517
页数:4
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