EFFECT OF TETRACYCLINES WHICH HAVE METALLOPROTEINASE INHIBITORY CAPACITY ON BASAL AND HEPARIN-STIMULATED BONE-RESORPTION BY CHICK OSTEOCLASTS
被引:16
作者:
CHOWDHURY, MH
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机构:LONG ISL JEWISH MED CTR,ALBERT EINSTEIN COLL MED,DIV RHEUMATOL,LONG ISL CAMPUS,NEW HYDE PK,NY 11042
CHOWDHURY, MH
MOAK, SA
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机构:LONG ISL JEWISH MED CTR,ALBERT EINSTEIN COLL MED,DIV RHEUMATOL,LONG ISL CAMPUS,NEW HYDE PK,NY 11042
MOAK, SA
RIFKIN, BR
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机构:LONG ISL JEWISH MED CTR,ALBERT EINSTEIN COLL MED,DIV RHEUMATOL,LONG ISL CAMPUS,NEW HYDE PK,NY 11042
RIFKIN, BR
GREENWALD, RA
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机构:LONG ISL JEWISH MED CTR,ALBERT EINSTEIN COLL MED,DIV RHEUMATOL,LONG ISL CAMPUS,NEW HYDE PK,NY 11042
GREENWALD, RA
机构:
[1] LONG ISL JEWISH MED CTR,ALBERT EINSTEIN COLL MED,DIV RHEUMATOL,LONG ISL CAMPUS,NEW HYDE PK,NY 11042
[2] NYU,SCH DENT MED,NEW YORK,NY 10003
来源:
AGENTS AND ACTIONS
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1993年
/
40卷
/
1-2期
关键词:
D O I:
10.1007/BF01976761
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Several tetracyclines (TETs) are potent inhibitors of collagenase (CGase) and can inhibit connective tissue degradation in a variety of inflammatory and degenerative disorders. The role of CGase in bone resorption by osteoclasts (OC) remains unclear. Disaggregated OCs from chick embryos were cultured for 24 h on devitalized bovine cortical bone + heparin in the presence of various TETs. Doxycycline (Dox) inhibited pit formation in a dose-dependent manner. CMT, a TET derivative which inhibits matrix metalloproteinases (MMPs) but is not antimicrobial, also inhibited chick OC bone resorption. Heparin markedly stimulated bone resorption at 5 mug/ml, which was reversed by Dox, 5 mug/ml. TETs can reversibly inhibit both basal and heparin-stimulated bone resorption by chick OCs. These findings suggest that MMPs may play a role in osteoclastic bone resorption, and that safe and effective inhibitors of MMPs, including certain TETs, might have a potential therapeutic role.