PROTEINOTOPIC FEATURE MAPS

被引:112
作者
MERELO, JJ
ANDRADE, MA
PRIETO, A
MORAN, F
机构
[1] UNIV GRANADA,FAC CIENCIAS,DEPT ELECTR & TECNOL COMPUTADORES,E-18071 GRANADA,SPAIN
[2] UNIV COMPLUTENSE,FAC QUIM,DEPT BIOQUIM & BIOL MOLEC 1,E-28040 MADRID,SPAIN
[3] UNIV PARIS 05,MED STAT LAB,F-75270 PARIS 06,FRANCE
[4] UNIV SO CALIF,BRAIN SIMULAT LAB,LOS ANGELES,CA 90089
[5] UNIV LIBRE BRUXELLES,B-1050 BRUSSELS,BELGIUM
[6] UNIV CALIF IRVINE,IRVINE,CA 92717
关键词
NEURAL NETWORK APPLICATIONS; SELF-ORGANIZING MAPS; CLASSIFICATION PROCEDURES; CIRCULAR DICHROISM; PROTEIN STRUCTURE;
D O I
10.1016/0925-2312(94)90021-3
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
In this paper a system based on Kohonen's SOM (Self-Organizing Map) for protein classification according to Circular Dichroism (CD) spectra is described. As a result, proteins with different secondary structures are clearly separated through a completely unsupervised training process. The algorithm is able to extract features from a high-dimensional vector (CD spectra) and map it to a 2-dimensional network. A new measure, called distortion, has been introduced to test SOM performance. Distortion can be used to fine tune and optimize some of the parameters of the SOM algorithm.
引用
收藏
页码:443 / 454
页数:12
相关论文
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