BINDING OF NUCLEAR PROTEINS TO TRANSCRIPTION REGULATORY ELEMENTS IN SELENIUM DEFICIENCY

被引：21

作者：

CHRISTENSEN, MJ

PUSEY, NW

机构：

[1] Department of Food Science and Nutrition, Brigham Young University, Provo

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1994年 / 1225卷 / 03期

关键词：

SELENIUM; GENE REGULATION; REGULATORY ELEMENT; NUCLEAR PROTEIN; ANTIOXIDANT;

D O I：

10.1016/0925-4439(94)90015-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dietary selenium deficiency in rats increased binding of liver nuclear proteins to DNA regulatory sequences which activate transcription in response to oxidative stress. In contrast, binding to the activator protein-1 control sequence, which is inhibited by oxidation, was decreased in selenium deficiency.

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页码：338 / 341

页数：4

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