HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY OF TAXOL

被引：84

作者：

RICHHEIMER, SL

TINNERMEIER, DM

TIMMONS, DW

机构：

[1] Hauser Chemical Research, Inc., Boulder

来源：

ANALYTICAL CHEMISTRY | 1992年 / 64卷 / 20期

关键词：

D O I：

10.1021/ac00044a004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A reversed-phase high-performance liquid chromatographic (HPLC) method for assaying taxol bulk drug or process samples is described. The method utilizes a commercially available pentafluorophenyl (PFP) packing material that has greater selectivity for taxol and related taxanes than other reversed-phase media tested. The method has been shown to be accurate, linear, precise, specific, and rugged, and can be used to assay the bulk drug and determine its chromatographic purity as well as to assay taxol In process and biomass samples.

引用

页码：2323 / 2326

页数：4

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