ENZYMATIC-SYNTHESIS OF OPTICALLY-ACTIVE 2-CARBAMOYL-OXYMETHYL-1,4-DIHYDROPYRIDINES, (R)-(+)-NB 818 AND (S)-(-)-NB 818

被引:19
作者
EBIIKE, H [1 ]
MARUYAMA, K [1 ]
ACHIWA, K [1 ]
机构
[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, 52-1 YADA, SHIZUOKA 422, JAPAN
关键词
D O I
10.1016/S0957-4166(00)82100-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Racemic dihydropyridines were resolved by enzyme-catalyzed hydrolysis in an organic solvent saturated with water. The chiral derivatives obtained were converted to (S)- and (R)-NB 818.
引用
收藏
页码:1153 / 1156
页数:4
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