DNA TOPOISOMERASE-II INHIBITION BY SUBSTITUTED 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES

被引：10

作者：

LEHNERT, EK ^{[1
]}

MILLER, KE ^{[1
]}

MADALENGOITIA, JS ^{[1
]}

GUZI, TJ ^{[1
]}

MACDONALD, TL ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(01)80400-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-aryl-1,2,3,4-tetrahydro-beta-carbolines were synthesized, as ''truncated'' analogs of the novel agent, azatoxin, and assayed in vitro for their ability to induce protein-associated DNA strand breaks in the presence of DNA and human DNA topoisomerase II.

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页码：2411 / 2416

页数：6

相关论文

共 16 条

[1] EXCEPTIONAL STEREOCHEMICAL CONTROL IN THE PICTET-SPENGLER REACTION [J].

BAILEY, PD ;

HOLLINSHEAD, SP ;

MCLAY, NR .

TETRAHEDRON LETTERS, 1987, 28 (43) :5177-5180

[2]

CHOW KC, 1988, MOL PHARMACOL, V34, P467

[3] DNA TOPOISOMERASE .2. A PRIMER ON THE ENZYME AND ITS UNIQUE ROLE AS A MULTIDRUG TARGET IN CANCER-CHEMOTHERAPY [J].

GLISSON, BS ;

ROSS, WE .

PHARMACOLOGY & THERAPEUTICS, 1987, 32 (02) :89-106

[4] CRYSTAL AND MOLECULAR-STRUCTURE OF 4'-(ACRIDIN-9-YLAMINO)METHANE-SULPHONANILIDE HYDROCHLORIDE, A COMPOUND SHOWING ANTILEUKEMIC ACTIVITY [J].

HALL, D ;

SWANN, DA ;

WATERS, TN .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1974, (11) :1334-1337

[5]

LETEURTRE F, 1992, CANCER RES, V52, P4478

[6]

LETEURTRE F, 1992, Proceedings of the American Association for Cancer Research Annual Meeting, V33, P434

[7] DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS [J].

LIU, LF .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :351-375

[8]

LOCK RB, 1987, ANTI-CANCER DRUG DES, V2, P151

[9]

MACDONALD TL, 1989, DNA TOPOISOMERASES C, P199

[10]

PEARCE H L, 1990, Proceedings of the American Association for Cancer Research Annual Meeting, V31, P441