DNA TOPOISOMERASE-II INHIBITION BY SUBSTITUTED 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES

被引：10

作者：

LEHNERT, EK ^{[1
]}

MILLER, KE ^{[1
]}

MADALENGOITIA, JS ^{[1
]}

GUZI, TJ ^{[1
]}

MACDONALD, TL ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(01)80400-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-aryl-1,2,3,4-tetrahydro-beta-carbolines were synthesized, as ''truncated'' analogs of the novel agent, azatoxin, and assayed in vitro for their ability to induce protein-associated DNA strand breaks in the presence of DNA and human DNA topoisomerase II.

引用

页码：2411 / 2416

页数：6

共 16 条

[11]

PETCHER TJ, 1972, J CHEM SOC P2, P288

[12] DNA UNWINDING AND INHIBITION OF MOUSE LEUKEMIA-L1210 DNA TOPOISOMERASE-I BY INTERCALATORS [J].