VAGINAL IMMUNIZATION OF MONKEYS AGAINST URINARY-TRACT INFECTION WITH A MULTI-STRAIN VACCINE

被引：20

作者：

UEHLING, DT ^{[1
]}

HOPKINS, WJ ^{[1
]}

JAMES, LJ ^{[1
]}

BALISH, E ^{[1
]}

机构：

[1] UNIV WISCONSIN, SCH MED, DEPT SURG UROL, MADISON, WI 53706 USA

来源：

JOURNAL OF UROLOGY | 1994年 / 151卷 / 01期

关键词：

IMMUNIZATION; URINARY TRACT INFECTIONS; MACACA-FASCICULARIS;

D O I：

10.1016/S0022-5347(17)34919-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cynomolgus monkeys were treated with a vaccine containing 10 heat-killed uropathogenic bacteria including 6 Escherichia coli strains. The multi-strain vaccine was administered either as a vaginal surface immunogen or intramuscularly. Following an induced E. coli cystitis, bladder infections were significantly reduced compared with controls at 1 and 2 weeks (intramuscular route) or 1 week (vaginal route) after UTI. This vaccine has been shown to be efficacious against cystitis in humans when given parenterally and has now proved efficacious in nonhuman primates by the vaginal mucosal route.

引用

页码：214 / 216

页数：3

共 19 条

[1]

EDEN CS, 1976, LANCET, V2, P490

[2] ROLE OF EXCRETORY UROGRAPHY AND CYSTOSCOPY IN THE EVALUATION AND MANAGEMENT OF WOMEN WITH RECURRENT URINARY-TRACT INFECTION [J].

ENGEL, G ;

SCHAEFFER, AJ ;

GRAYHACK, JT ;

WENDEL, EF .

JOURNAL OF UROLOGY, 1980, 123 (02) :190-191

[3] URINARY SLGA IN CHILDREN WITH URINARY-TRACT INFECTION [J].

FLIEDNER, M ;

MEHLS, O ;

RAUTERBERG, EW ;

RITZ, E .

JOURNAL OF PEDIATRICS, 1986, 109 (03) :416-421

[4] ORAL IMMUNOTHERAPY IN PARAPLEGIC PATIENTS WITH CHRONIC URINARY-TRACT INFECTIONS - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

HACHEN, HJ .

JOURNAL OF UROLOGY, 1990, 143 (04) :759-763

[5] LOCAL AND SYSTEMIC ANTIBODY-RESPONSES ACCOMPANY SPONTANEOUS RESOLUTION OF EXPERIMENTAL CYSTITIS IN CYNOMOLGUS MONKEYS [J].

HOPKINS, WJ ;

UEHLING, DT ;

BALISH, E .

INFECTION AND IMMUNITY, 1987, 55 (09) :1951-1956

[6]

HOPKINS WJ, 1990, INFECT UROL, V3, P128

[7] URINARY ANTIBODY-RESPONSE AFTER IMMUNIZATION WITH A VACCINE AGAINST URINARY-TRACT INFECTION [J].

KRUZE, D ;

HOLZBECHER, K ;

ANDRIAL, M ;

BOSSART, W .

UROLOGICAL RESEARCH, 1989, 17 (06) :361-366

[8]

LAYTON GT, 1983, CLIN EXP IMMUNOL, V54, P305

[9] RELATIONSHIP AMONG VESICOURETERAL REFLUX, P-FIMBRIATED ESCHERICHIA-COLI, AND ACUTE PYELONEPHRITIS IN CHILDREN WITH FEBRILE URINARY-TRACT INFECTION [J].

MAJD, M ;

RUSHTON, HG ;

JANTAUSCH, B ;

WIEDERMANN, BL .

JOURNAL OF PEDIATRICS, 1991, 119 (04) :578-585

[10] PREVENTION OF PYELONEPHRITIS BY IMMUNIZATION WITH P-FIMBRIAE [J].

ROBERTS, JA ;

HARDAWAY, K ;

KAACK, B ;

FUSSELL, EN ;

BASKIN, G .

JOURNAL OF UROLOGY, 1984, 131 (03) :602-607

← 1 2 →