THE MYOTONIN-PROTEIN KINASE PHOSPHORYLATES TYROSINE RESIDUES IN NORMAL HUMAN SKELETAL-MUSCLE

被引：15

作者：

ETONGUEMAYER, P

FAURE, R

BOUCHARD, JP

THIBAULT, MC

PUYMIRAT, J

机构：

[1] CHU LAVAL,RES CTR,DEPT MED & MOLEC GENET,ST FOY G1V 4G2,PQ,CANADA

[2] HOP ENFANTS JESUS,QUEBEC CITY,PQ,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a first approach to study the cellular events involved in myotonic dystrophy, we have produced a polyclonal antibody against a peptide sequence of the predicted gene product. This antibody specifically recognizes a 54 kDa protein in human skeletal muscle. This protein phosphorylates a co-polymer Glu/Tyr but not Myelin Basic Protein. This indicates that the myotonin-protein kinase has a tyrosine kinase activity in human skeletal muscle. This is the first demonstration of the kinase activity of the myotonin-protein kinase. (C) 1994 Academic Press, Inc.

引用

页码：89 / 92

页数：4

共 13 条

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