ACTIVIN SIGNALING AND RESPONSE TO A MORPHOGEN GRADIENT

被引：308

作者：

GURDON, JB ^{[1
]}

HARGER, P ^{[1
]}

MITCHELL, A ^{[1
]}

LEMAIRE, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 3EJ,ENGLAND

来源：

NATURE | 1994年 / 371卷 / 6497期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/371487a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Using combinations of amphibian embryo tissues, it is shown that the selection of genes expressed by a cell is determined by its distance from a source of activin, a peptide growth factor contained in vegetal cells and able to induce other cells to form mesoderm. This long-range signal spreads over at least 10 cell diameters In a few hours. It does so by passive diffusion, because It can by-pass cells that do not themselves respond to the signal nor synthesize protein. These results provide direct support for the operation of a morphogen concentration gradient In vertebrate development.

引用

页码：487 / 492

页数：6

共 47 条

[41] ACTIVINS ARE EXPRESSED EARLY IN XENOPUS EMBRYOGENESIS AND CAN INDUCE AXIAL MESODERM AND ANTERIOR STRUCTURES
THOMSEN, G
WOOLF, T
WHITMAN, M
SOKOL, S
VAUGHAN, J
VALE, W
MELTON, DA
[J]. CELL, 1990, 63 (03) : 485 - 493
[42] PROCESSED VG1 PROTEIN IS AN AXIAL MESODERM INDUCER IN XENOPUS
THOMSEN, GH
MELTON, DA
[J]. CELL, 1993, 74 (03) : 433 - 441
[43] A QUANTITATIVE-ANALYSIS OF THE EFFECT OF ALL-TRANS-RETINOIC ACID ON THE PATTERN OF CHICK WING DEVELOPMENT
TICKLE, C
LEE, J
EICHELE, G
[J]. DEVELOPMENTAL BIOLOGY, 1985, 109 (01) : 82 - 95
[44] LOCAL APPLICATION OF RETINOIC ACID TO THE LIMB BOND MIMICS THE ACTION OF THE POLARIZING REGION
TICKLE, C
ALBERTS, B
WOLPERT, L
LEE, J
[J]. NATURE, 1982, 296 (5857) : 564 - 566
[45] DROSOPHILA WINGLESS SUSTAINS ENGRAILED EXPRESSION ONLY IN ADJOINING CELLS - EVIDENCE FROM MOSAIC EMBRYOS
VINCENT, JP
LAWRENCE, PA
[J]. CELL, 1994, 77 (06) : 909 - 915
[46] MESODERMAL PATTERNING BY AN INDUCER GRADIENT DEPENDS ON SECONDARY CELL-CELL COMMUNICATION
WILSON, PA
MELTON, DA
[J]. CURRENT BIOLOGY, 1994, 4 (08) : 676 - 686
[47] WOLPERT L, 1989, DEVELOPMENT S, P3

← 1 2 3 4 5 →