PLATELET-ACTIVATING-FACTOR (PAF) AND THE DEVELOPMENT OF CHRONIC SUBDURAL-HEMATOMA

被引：16

作者：

HIRASIMA, Y ^{[1
]}

ENDO, S ^{[1
]}

KATO, R ^{[1
]}

OHMORI, T ^{[1
]}

NAGAHORI, T ^{[1
]}

NISHIJIMA, M ^{[1
]}

KARASAWA, K ^{[1
]}

NOJIMA, S ^{[1
]}

TAKAKU, A ^{[1
]}

机构：

[1] TEIKYO UNIV,FAC PHARMACEUT SCI,TOKYO 173,JAPAN

来源：

ACTA NEUROCHIRURGICA | 1994年 / 129卷 / 1-2期

关键词：

CHRONIC SUBDURAL HEMATOMA; HISTOCHEMISTRY; PAF-ACETYLHYDROLASE; PLATELET-ACTIVATING FACTOR;

D O I：

10.1007/BF01400868

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Platelet activating factor (PAF) content and PAF-acetylhydrolase (PAFAH) activity were measured in the plasma and haematoma of 34 chronic subdural haematoma (CSH) patients. The plasma PAF level in patients with CSH was higher than that in healthy controls. Although there was no correlation between the plasma PAF levels and the interval between the onset of symptoms and the day of sampling, namely, the interval after bleeding, the haematoma PAF level gradually decreased according to the interval after the onset of symptoms. There was no difference between plasma PAFAH activity in patients with CSH and that in healthy controls, and haematoma enzyme activity gradually increased correlated with the interval between the onset of symptoms and surgery. In addition, the localization of PAF in haematoma capsules was histochemically determined. PAF was solely localized to the peri-sinusoidal vessels in the outer membrane of haematoma capsules. Based on these biochemical and histochemical studies, we speculated that PAF may play a role in the development of chronic subdural haematomas.

引用

页码：20 / 25

页数：6

共 25 条

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