CIRCADIAN REACTIVITY RHYTHM OF HUMAN SKIN TO HOUSE DUST, PENICILLIN, AND HISTAMINE

被引:71
作者
REINBERG, A
ZAGULAMA.Z
GHATA, J
HALBERG, F
机构
[1] Service d'Allergie, the Laboratoire de Physiologie of the Fondation A. de Rothschild, Paris
[2] the Chronobiology Laboratories, Department of Pathology, University of Minnesota Medical School. Minneapolis, MN
来源
JOURNAL OF ALLERGY | 1969年 / 44卷 / 05期
基金
美国国家航空航天局;
关键词
D O I
10.1016/0021-8707(69)90034-3
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Circadian rhythms characterize the extent of erythematous allergic response to fixed doses of house dust extract as well as penicillin. In the evening for diurnally active man, or, more generally, during the interval from 17.5 to 19.5 hours following the midpoint of the daily sleep span, a positive test may be more readily elicited than at other test times. Crests in the susceptibility rhythm to the allergens coincide roughly with the peaks of statistically significant changes characterizing the response of healthy subjects to a fixed dose of histamine and occur near the circadian trough in plasma corticosteroid levels, gauged in this study by urinary 17-hydroxycorticosteroid (17-OHCS) determinations. The findings, evaluated by electronic computer procedures, reveal the basic periodicity in man's susceptibility to a broad range of potentially harmful agents, while accounting on the practical side for some of the variability in cutaneous test results. © 1969.
引用
收藏
页码:292 / &
相关论文
共 31 条
[1]  
Aschoff J, 1965, CIRCADIAN CLOCKS, P214
[2]   A MAP OF BLOOD AND URINARY CHANGES RELATED TO CIRCADIAN VARIATIONS IN ADRENAL CORTICAL FUNCTION IN NORMAL SUBJECTS [J].
BARTTER, FC ;
DELEA, CS ;
HALBERG, F .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1962, 98 (04) :969-+
[3]   CHANGES DURING 24 HOURS IN LUNG FUNCTION AND HISTAMINE HYPERREACTIVITY OF BRONCHIAL TREE IN ASTHMATIC AND BRONCHITIC PATIENTS [J].
DEVRIES, K ;
GOEI, JT ;
BOOYNOORD, H ;
ORIE, NGM .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1962, 20 (02) :93-&
[4]  
FOMAN SJ, 1961, 39 ROSS C PED RES CO
[5]  
GORDON RD, 1968, CLIN SCI, V35, P307
[6]   TEMPORAL COORDINATION OF PHYSIOLOGIC FUNCTION [J].
HALBERG, F .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1960, 25 :289-310
[7]  
HALBERG F, 1967, J PHYSIOLOGY PARIS, V59, P117
[8]  
HALBERG F, 1955, P SOC EXP BIOL MED, V88, P169
[9]  
HALBERG F., 1960, PERSPECTIVES IN BOL AND MED, V3, P491
[10]  
HALBERG F, 1965, ACTA ENDOCR-COP S103, V50, P1