CIRCADIAN REACTIVITY RHYTHM OF HUMAN SKIN TO HOUSE DUST, PENICILLIN, AND HISTAMINE

被引:71
作者
REINBERG, A
ZAGULAMA.Z
GHATA, J
HALBERG, F
机构
[1] Service d'Allergie, the Laboratoire de Physiologie of the Fondation A. de Rothschild, Paris
[2] the Chronobiology Laboratories, Department of Pathology, University of Minnesota Medical School. Minneapolis, MN
来源
JOURNAL OF ALLERGY | 1969年 / 44卷 / 05期
基金
美国国家航空航天局;
关键词
D O I
10.1016/0021-8707(69)90034-3
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Circadian rhythms characterize the extent of erythematous allergic response to fixed doses of house dust extract as well as penicillin. In the evening for diurnally active man, or, more generally, during the interval from 17.5 to 19.5 hours following the midpoint of the daily sleep span, a positive test may be more readily elicited than at other test times. Crests in the susceptibility rhythm to the allergens coincide roughly with the peaks of statistically significant changes characterizing the response of healthy subjects to a fixed dose of histamine and occur near the circadian trough in plasma corticosteroid levels, gauged in this study by urinary 17-hydroxycorticosteroid (17-OHCS) determinations. The findings, evaluated by electronic computer procedures, reveal the basic periodicity in man's susceptibility to a broad range of potentially harmful agents, while accounting on the practical side for some of the variability in cutaneous test results. © 1969.
引用
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页码:292 / &
相关论文
共 31 条
[21]  
NELSON W, 1966, HANDBOOK ENVIRONMENT, P586
[22]   CIRCADIAN CHANGES IN INHIBITORY EFFECTS OF AN ANTIHISTAMINIC DRUG IN MAN [J].
REINBERG, A ;
SIDI, E .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1966, 46 (04) :415-&
[23]  
REINBERG A, 1967, PERSPECT BIOL MED, V11, P111, DOI 10.1353/pbm.1967.0025
[24]   CIRCADIAN REACTIVITY RHYTHMS OF HUMAN SKIN TO HISTAMINE OR ALLERGEN AND ADRENAL CYCLE [J].
REINBERG, A ;
SIDI, E ;
GHATA, J .
JOURNAL OF ALLERGY, 1965, 36 (03) :273-&
[25]   NOCTURNAL ASTHMA ATTACKS - THEIR RELATIONSHIP TO CIRCADIAN ADRENAL CYCLE [J].
REINBERG, A ;
GHATA, J ;
SIDI, E .
JOURNAL OF ALLERGY, 1963, 34 (04) :323-&
[26]   A CIRCADIAN SUSCEPTIBILITY RHYTHM IN RATS TO PENTOBARBITAL SODIUM [J].
SCHEVING, LE ;
VEDRAL, DF ;
PAULY, JE .
ANATOMICAL RECORD, 1968, 160 (04) :741-&
[27]  
SCHEVING LE, 1966, ANAT REC, V154, P417
[28]  
SCHOLLER R, 1957, SEM HOP PARIS ARCH B, V33, P2
[29]  
SHELLEY WB, 1962, JAMA, V182, P170
[30]  
Stroebel C F, 1967, Proc Annu Meet Am Psychopathol Assoc, V55, P158