NEOPTERIN AS AN ENDOGENOUS ANTIOXIDANT

被引:65
作者
KOJIMA, S [1 ]
ICHO, T [1 ]
KAJIWARA, Y [1 ]
KUBOTA, K [1 ]
机构
[1] SCI UNIV TOKYO,BIOSCI RES INST,TOKYO 162,JAPAN
关键词
NEOPTERIN; ANTIOXIDANT; ALLOXAN DIABETES;
D O I
10.1016/0014-5793(92)80610-S
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The in vitro potency of neopterin (NP) as an antioxidant and its in vivo activity to suppress alloxan-induced diabetes were investigated. The reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH-4), showed an extremely high superoxide anion radical scavenging activity in two assay systems, i.e. xanthine/xanthine oxidase- and macrophage/phorbol myristate acetate (PMA)-reaction systems. NPH-4 also inhibited the oxidation of linoleic acid about as effectively as uric acid. Furthermore, NPH-4 and NP effectively suppressed alloxan-induced mouse diabetes. These results suggest that pteridines play an important role as endogenous antioxidants.
引用
收藏
页码:163 / 166
页数:4
相关论文
共 19 条
  • [1] ABITA JP, 1985, LANCET, V2, P51
  • [2] DEPENDENCE ON O-2- GENERATION BY XANTHINE-OXIDASE OF PATHOGENESIS OF INFLUENZA-VIRUS INFECTION IN MICE
    AKAIKE, T
    ANDO, M
    ODI, T
    DOI, T
    IJIRI, S
    ARAKI, S
    MAEDA, H
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (03) : 739 - 745
  • [3] FISHER LJ, 1980, DIABETES, V29, P213
  • [4] FISHER LJ, 1980, LIFE SCI, V26, P1405
  • [5] SUPEROXIDE-DISMUTASE, CATALASE AND SCAVENGERS OF HYDROXYL RADICAL PROTECT AGAINST THE TOXIC ACTION OF ALLOXAN ON PANCREATIC-ISLET CELLS INVITRO
    GRANKVIST, K
    MARKLUND, S
    SEHLIN, J
    TALJEDAL, IB
    [J]. BIOCHEMICAL JOURNAL, 1979, 182 (01) : 17 - 25
  • [6] IMMUNE-RESPONSE ASSOCIATED PRODUCTION OF NEOPTERIN - RELEASE FROM MACROPHAGES PRIMARILY UNDER CONTROL OF INTERFERON-GAMMA
    HUBER, C
    BATCHELOR, JR
    FUCHS, D
    HAUSEN, A
    LANG, A
    NIEDERWIESER, D
    REIBNEGGER, G
    SWETLY, P
    TROPPMAIR, J
    WACHTER, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (01) : 310 - 316
  • [7] HUBER C, 1983, J IMMUNOL, V130, P1047
  • [9] A HIGHLY SENSITIVE METHOD FOR DETERMINING BOTH MN-ZN AND CU-ZN SUPEROXIDE-DISMUTASE ACTIVITIES IN TISSUES AND BLOOD-CELLS
    NAKANO, M
    KIMURA, H
    HARA, M
    KUROIWA, M
    KATO, M
    TOTSUNE, K
    YOSHIKAWA, T
    [J]. ANALYTICAL BIOCHEMISTRY, 1990, 187 (02) : 277 - 280
  • [10] Nathan C F, 1986, Interferon, V7, P125