HIGH-RESOLUTION SOLUTION STRUCTURE OF THE BETA-CHEMOKINE HMIP-1-BETA BY MULTIDIMENSIONAL NMR

被引:217
作者
LODI, PJ
GARRETT, DS
KUSZEWSKI, J
TSANG, MLS
WEATHERBEE, JA
LEONARD, WJ
GRONENBORN, AM
CLORE, GM
机构
[1] NIDDKD,CHEM PHYS LAB,BETHESDA,MD 20892
[2] R&D SYST INC,MINNEAPOLIS,MN 55413
[3] NHLBI,PULM & MOLEC IMMUNOL SECT,BETHESDA,MD 20892
关键词
D O I
10.1126/science.8134838
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The three-dimensional structure of a member of the beta subfamily of chemokines, human macrophage inflammatory protein-1 beta (hMIP-1 beta), has been determined with the use of solution multidimensional heteronuclear magnetic resonance spectroscopy. Human MIP-1 beta is a symmetric homodimer with a relative molecular mass of similar to 16 kilodaltons. The structure of the hMIP-1 beta monomer is similar to that of the related alpha chemokine interleukin-8 (IL-8). However, the quaternary structures of the two proteins are entirely distinct, and the dimer interfaceis formed by a completely different set of residues. Whereas the IL-8 dimer is globular, the hMIP-1 beta dimer is elongated and cylindrical. This provides a rational explanation for the absence of cross-binding and reactivity between the alpha and beta chemokine subfamilies. Calculation of the solvation free energies of dimerization suggests that the formation and stabilization of the two different types of dimers arise from the burial of hydrophobic residues.
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页码:1762 / 1767
页数:6
相关论文
共 60 条
  • [41] PROPERTIES OF THE NOVEL PROINFLAMMATORY SUPERGENE INTERCRINE CYTOKINE FAMILY
    OPPENHEIM, JJ
    ZACHARIAE, COC
    MUKAIDA, N
    MATSUSHIMA, K
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 : 617 - 648
  • [42] THE HIGH-RESOLUTION, 3-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 DETERMINED BY MULTIDIMENSIONAL HETERONUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY
    POWERS, R
    GARRETT, DS
    MARCH, CJ
    FRIEDEN, EA
    GRONENBORN, AM
    CLORE, GM
    [J]. BIOCHEMISTRY, 1993, 32 (26) : 6744 - 6762
  • [43] COOPERATIVE DIMERIC AND TETRAMERIC CLAM HEMOGLOBINS ARE NOVEL ASSEMBLAGES OF MYOGLOBIN FOLDS
    ROYER, WE
    LOVE, WE
    FENDERSON, FF
    [J]. NATURE, 1985, 316 (6025) : 277 - 280
  • [44] IDENTIFICATION AND CHARACTERIZATION OF SPECIFIC RECEPTORS FOR MONOCYTE-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR (MDNCF) ON HUMAN-NEUTROPHILS
    SAMANTA, AK
    OPPENHEIM, JJ
    MATSUSHIMA, K
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) : 1185 - 1189
  • [45] HUMAN MACROPHAGE INFLAMMATORY PROTEIN-ALPHA (MIP-1-ALPHA) AND MIP-1-BETA CHEMOKINES ATTRACT DISTINCT POPULATIONS OF LYMPHOCYTES
    SCHALL, TJ
    BACON, K
    CAMP, RDR
    KASPARI, JW
    GOEDDEL, DV
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) : 1821 - 1825
  • [46] BIOLOGY OF THE RANTES/SIS CYTOKINE FAMILY
    SCHALL, TJ
    [J]. CYTOKINE, 1991, 3 (03) : 165 - 183
  • [47] STRUCTURE OF A LEGUME LECTIN WITH AN ORDERED N-LINKED CARBOHYDRATE IN COMPLEX WITH LACTOSE
    SHAANAN, B
    LIS, H
    SHARON, N
    [J]. SCIENCE, 1991, 254 (5033) : 862 - 866
  • [48] STEVENS AAE, UNPUB
  • [49] T-CELL ADHESION INDUCED BY PROTEOGLYCAN-IMMOBILIZED CYTOKINE MIP-1-BETA
    TANAKA, Y
    ADAMS, DH
    HUBSCHER, S
    HIRANO, H
    SIEBENLIST, U
    SHAW, S
    [J]. NATURE, 1993, 361 (6407) : 79 - 82
  • [50] PREFERENTIAL MIGRATION OF ACTIVATED CD4+ AND CD8+ T-CELLS IN RESPONSE TO MIP-1-ALPHA AND MIP-1-BETA
    TAUB, DD
    CONLON, K
    LLOYD, AR
    OPPENHEIM, JJ
    KELVIN, DJ
    [J]. SCIENCE, 1993, 260 (5106) : 355 - 358