LONG-TERM EFFECTS OF L-THYROXINE THERAPY FOR CONGENITAL HYPOTHYROIDISM

被引:108
作者
ROVET, JF
EHRLICH, RM
机构
[1] UNIV TORONTO, DEPT PEDIAT, DIV ENDOCRINOL, TORONTO, ON, CANADA
[2] UNIV TORONTO, DEPT PSYCHOL, TORONTO, ON, CANADA
关键词
D O I
10.1016/S0022-3476(95)70452-3
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To study the effects of initial and concurrent dose levels of L-thyroxine on ability and behavior in children with congenital hypothyroidism. Methods: An existing database, involving a large cohort of children with congenital hypothyroidism detected by neonatal screening, was analyzed retrospectively, There were 94 children: 89 were assessed at age 7 years for intelligence and selective cognitive abilities, and 87 at age 8 years for behavior, achievement, and selective abilities. Results: Subjects were stratified by median spilt into low and high starting dose groups. The high-dose group performed better on indexes of intelligence, verbal ability, and memory but had more behavior problems reflecting increased anxiety, social withdrawal, and poorer concentration. The dose of L-thyroxine at age 8 years was negatively correlated with memory task performance. Conclusion: A higher starting dose of L-thyroxine is beneficial for subsequent intellectual outcome in children with congenital hypothyroidism but may be associated with internalizing behavior problems.
引用
收藏
页码:380 / 386
页数:7
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