ROLE OF GLYCOSAMINOGLYCANS IN DIABETIC NEPHROPATHY

被引:24
作者
GAMBARO, G [1 ]
BAGGIO, B [1 ]
机构
[1] UNIV PADUA, SCH MED,INST INTERNAL MED,DIV NEPHROL, VIA GIUSTINIANI 2, I-35128 PADUA, ITALY
关键词
DIABETIC NEPHROPATHY; GLOMERULAR BASEMENT MEMBRANE; GROWTH FACTORS; GLYCOSAMINOGLYCANS; HEPARAN SULFATE;
D O I
10.1007/BF00573480
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A number of abnormalities of glycosaminoglycan metabolism have been reported in diabetes mellitus. These include anomalous synthesis, catabolism and sulphation. In this review glycosaminoglycan metabolism in diabetes mellitus is discussed with reference to its possible impact on glomerular basement membrane permeability, and on the physiology and metabolism of glomerular resident cells, specifically of the mesangium. Experimental results demonstrating favourable therapeutic activities of some glycosaminoglycans in mesangioproliferative glomerulitis and diabetic nephropathy are reported. These pharmacological actions do not depend on the well-known anticoagulative activity of glycosaminoglycans, but most probably on their antiproliferative effect. A more complex role of glycosaminoglycans in the pathogenesis of diabetic nephropathy is suggested.
引用
收藏
页码:149 / 155
页数:7
相关论文
共 88 条
  • [1] INHIBITION OF RAT GLOMERULAR VISCERAL EPITHELIAL-CELL GROWTH BY HEPARIN
    ADLER, S
    KOPASZ, T
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (04): : F781 - F786
  • [3] BELTRAMO E, 1992, 1ST P CONV NAZ PROG, P184
  • [4] TRANSFORMING GROWTH FACTOR-B REGULATES PRODUCTION OF PROTEOGLYCANS BY MESANGIAL CELLS
    BORDER, WA
    OKUDA, S
    LANGUINO, LR
    RUOSLAHTI, E
    [J]. KIDNEY INTERNATIONAL, 1990, 37 (02) : 689 - 695
  • [5] BORDER WA, 1991, J NEPHROL, V4, P112
  • [6] MOLECULAR-BASIS OF PROTEINURIA OF GLOMERULAR ORIGIN
    BRENNER, BM
    HOSTETTER, TH
    HUMES, HD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1978, 298 (15) : 826 - 833
  • [7] S-35-LABELED GLYCOSAMINOGLYCAN AND S-35-LABELED GLYCOPEPTIDE METABOLISM BY DIABETIC GLOMERULI AND AORTA
    BROWN, DM
    KLEIN, DJ
    MICHAEL, AF
    OEGEMA, TR
    [J]. DIABETES, 1982, 31 (05) : 418 - 425
  • [8] CALDWELL RB, 1986, INVEST OPHTH VIS SCI, V27, P1691
  • [9] STRUCTURAL DETERMINANTS OF THE CAPACITY OF HEPARIN TO INHIBIT THE PROLIFERATION OF VASCULAR SMOOTH-MUSCLE CELLS
    CASTELLOT, JJ
    BEELER, DL
    ROSENBERG, RD
    KARNOVSKY, MJ
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1984, 120 (03) : 315 - 320
  • [10] BINDING AND INTERNALIZATION OF HEPARIN BY VASCULAR SMOOTH-MUSCLE CELLS
    CASTELLOT, JJ
    WONG, K
    HERMAN, B
    HOOVER, RL
    ALBERTINI, DF
    WRIGHT, TC
    CALEB, BL
    KARNOVSKY, MJ
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1985, 124 (01) : 13 - 20